The Domus Sessoriana is located within an archaeological site that includes the ruins of the Temple of Venus and Cupid, which in times past housed Councils of State, and the magnificent Castrensian Amphitheatre, built around the time of Emperor Heliogabalus (212-222). The Amphitheatre used to host gladiatorial games and fights between humans and wild animals; now it is home to the Holy Cross in Jerusalem Vegetable Garden.
The building of the Domus Sessoriana is divided into two sections.